G6PC CLIA Kit for Human(Homo sapiens) | EIAab.comG6PC CLIA Kit for Human(Homo sapiens)

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Index > Protein center > G6PC(Gene name) > Human

G6PC (Gene name),

Glucose-6-phosphatase (Protein name ), G6PC_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

G6PC(G6PT);

Protein name:

Glucose-6-phosphatase(G-6-Pase;G6Pase);

Alternative:

Glucose-6-phosphatase alpha(G6Pase-alpha);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.

Subcellular Location:

Endoplasmic reticulum membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

357

Sequence:

50:

100:

150:

200:

250:

300:

350:

357:

QPHKKSL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:2538

UniGene:

Hs.212293

Pfam:

PF01569

String:

P35575

MIM:

232200

STRING:

9606.ENSP00000253801

Uniprot:

P35575

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ELISA Kit for Human G-6-Pase

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E13766m

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96T

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ELISA Kit for Human G-6-Pase

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E13766d

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96T

ELISA Kit for Human G-6-Pase

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E13766b

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96T

ELISA Kit for Human G-6-Pase

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E13766h

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96T

ELISA Kit for Human G-6-Pase

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E13766r

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96T

CLIA Kit for Human G-6-Pase

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U13766b

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96T

CLIA Kit for Human G-6-Pase

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U13766d

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96T

CLIA Kit for Human G-6-Pase

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U13766r

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96T

CLIA Kit for Human G-6-Pase

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U13766h

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96T

CLIA Kit for Human G-6-Pase

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U13766m

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96T

Polyclonal Antibody for Human G-6-Pase

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P13766Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human G-6-Pase

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P13766Rb-m

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Polyclonal Antibody for Human G-6-Pase

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P13766Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human G-6-Pase

Monoclonal Antibody for Human G-6-Pase

Protein for Human G-6-Pase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Mutations in the glucose-6-phosphatase gene that cause glycogen storage disease type 1a."
Lei K.-J. , Shelly L.L. , Pan C.-J. , Sidbury J.B. , Chou J.Y.
Science262:580-583(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Liver.
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Liver.
3.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.

"Asparagine-linked oligosaccharides are localized to a luminal hydrophilic loop in human glucose-6-phosphatase."
Pan C.J. , Lei K.J. , Chou J.Y.
J. Biol. Chem.273:21658-21662(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-96
6.

"The catalytic center of glucose-6-phosphatase. HIS176 is the nucleophile forming the phosphohistidine-enzyme intermediate during catalysis."
Ghosh A. , Shieh J.-J. , Pan C.-J. , Sun M.-S. , Chou J.Y.
J. Biol. Chem.277:32837-32842(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVE SITES;MUTAGENESIS OF HIS-9; HIS-52; HIS-119; HIS-176; HIS-179; HIS-197; HIS-252; HIS-307 AND HIS-353;CHARACTERIZATION OF VARIANTS ASN-76; CYS-83 AND GLN-170
7.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96
tissue: Liver.
8.

"Identification of mutations in the gene for glucose-6-phosphatase, the enzyme deficient in glycogen storage disease type 1a."
Lei K.J. , Pan C.J. , Shelly L.L. , Liu J.L. , Chou J.Y.
J. Clin. Invest.93:1994-1999(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GSD1A CYS-83
9.

"Genetic basis of glycogen storage disease type 1a: prevalent mutations at the glucose-6-phosphatase locus."
Lei K.-J. , Chen Y.-T. , Chen H. , Wong L.-J.C. , Liu J.-L. , McConkie-Rosell A. , van Hove J.L.K. , Ou H.C.-Y. , Yeh N.J. , Pan L.Y. , Chou J.Y.
Am. J. Hum. Genet.57:766-771(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GSD1A
10.

"Characterization of the mutations in the glucose-6-phosphatase gene in Israeli patients with glycogen storage disease type 1a: R83C in six Jews and a novel V166G mutation in a Muslim Arab."
Parvari R. , Moses S. , Hershkovitz E. , Carmi R. , Bashan N.
J. Inherit. Metab. Dis.18:21-27(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GSD1A CYS-83 AND GLY-166
11.

"Glucose-6-phosphatase gene G327A mutation is common in Chinese patients with glycogen storage disease type Ia."
Hwu W.-L. , Chuang S.-C. , Tsai L.-P. , Chang M.-H. , Chuang S.-M. , Wang T.-R.
Hum. Mol. Genet.4:1095-1096(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GSD1A ILE-83
12.

"Genetic analysis of the glucose-6-phosphatase mutation of type 1a glycogen storage disease in a Chinese family."
Lee W.J. , Lee H.M. , Chi C.S. , Shu S.G. , Lin L.Y. , Lin W.H.
Clin. Genet.50:206-211(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GSD1A HIS-83 AND ASN-341
13.

"Mutation analysis in 24 French patients with glycogen storage disease type 1a."
Chevalier-Porst F. , Bozon D. , Bonardot A.-M. , Bruni N. , Mithieux G. , Mathieu M. , Maire I.
J. Med. Genet.33:358-360(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GSD1A VAL-38; ARG-77; LYS-110; THR-124; GLU-184; ARG-188 AND PRO-211
14.

"Glycogen storage disease type 1a in Israel: biochemical, clinical, and mutational studies."
Parvari R. , Lei K.J. , Bashan N. , Hershkovitz E. , Korman S.H. , Barash V. , Lerman-Sagie T. , Mandel H. , Chou J.Y. , Moses S.W.
Am. J. Med. Genet.72:286-290(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GSD1A CYS-83 AND GLY-166
15.

"Molecular aspects of glycogen storage disease type Ia in Turkish patients: a novel mutation in the glucose-6-phosphatase gene."
Huener G. , Podskarbi T. , Schuetz M. , Baykal T. , Sarbat G. , Shin Y.S. , Demirkol M.
J. Inherit. Metab. Dis.21:445-446(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GSD1A CYS-83; GLN-170 AND TRP-270
16.

"A novel mutation in a Brazilian patient with glycogen storage disease type 1a."
Sartorato E.L. , Reis F.C. , Norato D.Y.J. , Hackel C.
J. Inherit. Metab. Dis.21:447-447(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GSD1A ARG-68
17.

"A new mutation of the glucose-6-phosphatase gene in a 4-year-old girl with oligosymptomatic glycogen storage disease type 1a."
Keller K.M. , Schuetz M. , Podskarbi T. , Bindl L. , Lentze M.J. , Shin Y.S.
J. Pediatr.132:360-361(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GSD1A CYS-83 AND LYS-264
18.

"Glycogen storage disease type Ia: four novel mutations (175delGG, R170X, G266V and V338F) identified."
Rake J.P. , ten Berge A.M. , Verlind E. , Visser G. , Niezen-Koning K.E. , Buys C.H.C.M. , Smit G.P. , Scheffer H.
Hum. Mutat.13:173-173(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GSD1A VAL-266 AND PHE-338
19.

"Identification of three novel mutations (Q54P, W70X and T108I) in the glucose-6-phosphatase gene of patients with glycogen storage disease type Ia."
Trioche P. , Francoual J. , Chalas J. , Capel L. , Bernard O. , Labrune P.
Hum. Mutat.14:91-91(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GSD1A PRO-54 AND ILE-108
20.

"Mutations in the glucose-6-phosphatase gene of 53 Italian patients with glycogen storage disease type Ia."
Stroppiano M. , Regis S. , DiRocco M. , Caroli F. , Gandullia P. , Gatti R.
J. Inherit. Metab. Dis.22:43-49(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GSD1A VAL-38; ARG-63; CYS-83; VAL-184; ARG-222; VAL-270; CYS-295; PRO-298 AND PHE-338
21.

"Glycogen storage disease type Ia: molecular diagnosis of 51 Japanese patients and characterization of splicing mutations by analysis of ectopically transcribed mRNA from lymphoblastoid cells."
Akanuma J. , Nishigaki T. , Fujii K. , Matsubara Y. , Inui K. , Takahashi K. , Kure S. , Suzuki Y. , Ohura T. , Miyabayashi S. , Ogawa E. , Iinuma K. , Okada S. , Narisawa K.
Am. J. Med. Genet.91:107-112(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GSD1A HIS-83; ASP-122; PRO-179 AND LEU-257
22.

"Molecular genetic analysis of 40 patients with glycogen storage disease type Ia: 100% mutation detection rate and 5 novel mutations."
Seydewitz H.H. , Matern D.
Hum. Mutat.15:115-116(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GSD1A ARG-20; ARG-81; LEU-156 AND ASP-188
23.

"Identification of a novel missense mutation (T16A) in the glucose-6-phosphatase gene in a Taiwan Chinese patient with glycogen storage disease Ia (von Gierke disease)."
Wu M.-C. , Tsai F.-J. , Lee C.-C. , Lin S.-P. , Wu J.-Y.
Hum. Mutat.15:390-390(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GSD1A ALA-16
24.

"Identification of mutations in the glucose-6-phosphatase gene in Czech and Slovak patients with glycogen storage disease type Ia, including novel mutations K76N, V166A and 540del5."
Kozak L. , Francova H. , Hrabincova E. , Stastna S. , Peskova K. , Elleder M.
Hum. Mutat.16:89-89(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GSD1A ASN-76; ARG-77; CYS-83; ALA-166; ARG-188 AND CYS-295
25.

"Genetic heterogeneity of glycogen storage disease type Ia in France: a study of 48 patients."
Trioche P. , Francoual J. , Chalas J. , Capel L. , Lindenbaum A. , Odievre M. , Labrune P.
Hum. Mutat.16:444-444(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GSD1A ARG-5; VAL-38; PRO-54; CYS-83; ILE-108; LYS-110; ILE-111; GLU-184; ARG-188; THR-241; ARG-270; VAL-270; LEU-322; PHE-327 DEL AND PHE-338
26.

"A novel missense mutation (H119L) identified in a Taiwan Chinese family with glycogen storage disease Ia (von Gierke disease)."
Wu M.-C. , Tsai F.-J. , Lee C.-C. , Tsai C.-H. , Wu J.-Y.
Hum. Mutat.16:447-447(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GSD1A LEU-119
27.

"Glucose-6-phosphatase mutation G188R confers an atypical glycogen storage disease type 1b phenotype."
Weston B.W. , Lin J.L. , Muenzer J. , Cameron H.S. , Arnold R.R. , Seydewitz H.H. , Mayatepek E. , Van Schaftingen E. , Veiga-da-Cunha M. , Matern D. , Chen Y.T.
Pediatr. Res.48:329-334(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GSD1A ARG-188
28.

"Glycogen storage disease type I: diagnosis and phenotype/genotype correlation."
Matern D. , Seydewitz H.H. , Bali D. , Lang C. , Chen Y.-T.
Eur. J. Pediatr.161:S10-S19(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GSD1A ARG-20; VAL-38; PRO-65; ARG-68; ARG-77; ARG-81; CYS-83; HIS-83; LYS-110; LEU-113; LEU-156; GLN-170; CYS-177; SER-178; ARG-188; SER-188; ARG-236; PRO-265; VAL-270; PHE-327 DEL AND ARG-345
29.

"Mutation frequencies for glycogen storage disease Ia in the Ashkenazi Jewish population."
Ekstein J. , Rubin B.Y. , Anderson S.L. , Weinstein D.A. , Bach G. , Abeliovich D. , Webb M. , Risch N.
Am. J. Med. Genet. A129:162-164(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GSD1A CYS-83
30.

"Mutation spectrum of the glucose-6-phosphatase gene and its implication in molecular diagnosis of Korean patients with glycogen storage disease type Ia."
Ki C.S. , Han S.H. , Kim H.J. , Lee S.G. , Kim E.J. , Kim J.W. , Choe Y.H. , Seo J.K. , Chang Y.J. , Park J.Y.
Clin. Genet.65:487-489(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GSD1A ASP-122; ALA-178 AND ILE-255
31.

"Glycogen storage disease type Ia in Argentina: two novel glucose-6-phosphatase mutations affecting protein stability."
Angaroni C.J. , de Kremer R.D. , Argarana C.E. , Paschini-Capra A.E. , Giner-Ayala A.N. , Pezza R.J. , Pan C.-J. , Chou J.Y.
Mol. Genet. Metab.83:276-279(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GSD1A ARG-16; PRO-54; CYS-83 AND CYS-209;CHARACTERIZATION OF VARIANTS GSD1A ARG-16 AND CYS-209
32.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-116

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